Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)
Identifieur interne : 000733 ( Main/Exploration ); précédent : 000732; suivant : 000734Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)
Auteurs : Carsten A. Vock [Allemagne] ; Anna K. Renfrew ; Rosario Scopelliti ; Lucienne Juillerat-Jeanneret [Suisse] ; Paul J. Dyson [Suisse]Source :
- European Journal of Inorganic Chemistry [ 1434-1948 ] ; 2008-04.
English descriptors
- KwdEn :
- Teeft :
- Aqueous nacl, Aqueous nacl solution, Bph4, Calcd, Cancer cells, Cdcl3, Cell line, Ch3cn, Chcl3 solution, Chem, Cochco, Cytotoxic, Cytotoxicity, Derivative, Diketonato ligand, Dyson, Equiv, Et2o, Ether, Full paper, General formula, Gmbh, High cytotoxicities, Hydrolysis behaviour, Inorg, Kgaa, Ligand, Me2acac, Mmol, More times, Nacl, Nacl solution, Nch2n, Nchahbn, Neutral complexes, Pch2n, Petroleum, Petroleum ether, Ph2acac, Reflux temperature, Relative collision energy, Room temperature, Sadler, Scopelliti, Sept, Tbu2acac, Temperature cycle, Total reaction time, Vacuo, Verlag, Verlag gmbh, Vock, Weinheim.
Abstract
A series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. The results indicate that hydrolysis may not be a prerequisite (or the first step) in their mode of action.
Url:
DOI: 10.1002/ejic.200701291
Affiliations:
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Renfrew</name></author><author><name sortKey="Scopelliti, Rosario" sort="Scopelliti, Rosario" uniqKey="Scopelliti R" first="Rosario" last="Scopelliti">Rosario Scopelliti</name></author><author><name sortKey="Juillerat Eanneret, Lucienne" sort="Juillerat Eanneret, Lucienne" uniqKey="Juillerat Eanneret L" first="Lucienne" last="Juillerat-Jeanneret">Lucienne Juillerat-Jeanneret</name></author><author><name sortKey="Dyson, Paul J" sort="Dyson, Paul J" uniqKey="Dyson P" first="Paul J." last="Dyson">Paul J. 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Chem.</title><idno type="ISSN">1434-1948</idno><idno type="eISSN">1099-0682</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2008-04">2008-04</date><biblScope unit="volume">2008</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1661">1661</biblScope><biblScope unit="page" to="1671">1671</biblScope></imprint><idno type="ISSN">1434-1948</idno></series><idno type="istex">0AAFB6BFA1498BF6AB0F73AB800226B58253AD30</idno><idno type="DOI">10.1002/ejic.200701291</idno><idno type="ArticleID">EJIC200701291</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1434-1948</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticancer drugs</term><term>Bioorganometallics</term><term>Metal‐based drugs</term><term>Ruthenium</term><term>X‐ray structure</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Aqueous nacl</term><term>Aqueous nacl solution</term><term>Bph4</term><term>Calcd</term><term>Cancer cells</term><term>Cdcl3</term><term>Cell line</term><term>Ch3cn</term><term>Chcl3 solution</term><term>Chem</term><term>Cochco</term><term>Cytotoxic</term><term>Cytotoxicity</term><term>Derivative</term><term>Diketonato ligand</term><term>Dyson</term><term>Equiv</term><term>Et2o</term><term>Ether</term><term>Full paper</term><term>General formula</term><term>Gmbh</term><term>High cytotoxicities</term><term>Hydrolysis behaviour</term><term>Inorg</term><term>Kgaa</term><term>Ligand</term><term>Me2acac</term><term>Mmol</term><term>More times</term><term>Nacl</term><term>Nacl solution</term><term>Nch2n</term><term>Nchahbn</term><term>Neutral complexes</term><term>Pch2n</term><term>Petroleum</term><term>Petroleum ether</term><term>Ph2acac</term><term>Reflux temperature</term><term>Relative collision energy</term><term>Room temperature</term><term>Sadler</term><term>Scopelliti</term><term>Sept</term><term>Tbu2acac</term><term>Temperature cycle</term><term>Total reaction time</term><term>Vacuo</term><term>Verlag</term><term>Verlag gmbh</term><term>Vock</term><term>Weinheim</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)</div><div type="abstract" xml:lang="en">Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. The results indicate that hydrolysis may not be a prerequisite (or the first step) in their mode of action.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>Canton de Vaud</li><li>Sarre (Land)</li></region><settlement><li>Lausanne</li><li>Sarrebruck</li></settlement></list><tree><noCountry><name sortKey="Renfrew, Anna K" sort="Renfrew, Anna K" uniqKey="Renfrew A" first="Anna K." last="Renfrew">Anna K. Renfrew</name><name sortKey="Scopelliti, Rosario" sort="Scopelliti, Rosario" uniqKey="Scopelliti R" first="Rosario" last="Scopelliti">Rosario Scopelliti</name></noCountry><country name="Allemagne"><region name="Sarre (Land)"><name sortKey="Vock, Carsten A" sort="Vock, Carsten A" uniqKey="Vock C" first="Carsten A." last="Vock">Carsten A. Vock</name></region><name sortKey="Vock, Carsten A" sort="Vock, Carsten A" uniqKey="Vock C" first="Carsten A." last="Vock">Carsten A. Vock</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Juillerat Eanneret, Lucienne" sort="Juillerat Eanneret, Lucienne" uniqKey="Juillerat Eanneret L" first="Lucienne" last="Juillerat-Jeanneret">Lucienne Juillerat-Jeanneret</name></region><name sortKey="Dyson, Paul J" sort="Dyson, Paul J" uniqKey="Dyson P" first="Paul J." last="Dyson">Paul J. Dyson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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